Article
Structure, diversity, and evolution of the T-cell receptor VB gene repertoire in primates.
Immunogenetics - 1 Jan 1994
Jaeger E E, Bontrop R E, Lanchbury J S
Abstract excerpt
AB T-cell receptors (TCR) that recognize major histocompatibility complex (MHC)/peptide antigen complexes regulate humoral and cellular arms of the adaptive immune response. Antigen binding sites of MHC and immunoglobulin heavy chain variable regions (Igh-V) are subject to diversity enhancing selection. We sought to establish whether positive Darwinian selection has driven diversity of TCRBV chains in the primate...
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