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Article

Key Role of the <i>Cdx2</i> Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation

15 Dec 1997

Abstract excerpt

To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 sense and antisense RNAs. Cdx1 overexpression or inhibition by antisense RNA does not markedly modify the cell differentiation markers analyzed in this study. In contrast, Cdx2 overexpression stimulates two typical markers of enterocytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9396760
DOI: 10.1083/jcb.139.6.1553

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