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Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2

18 Mar 2005

Abstract excerpt

We have examined the role that the caudal-related homeobox transcription factors Cdx1 and Cdx2 play in activating the enterocyte differentiation marker gene intestinal alkaline phosphatase (IAP). Human colon cancer Caco-2 cells were transiently transfected with Cdx1 and/or Cdx2, and semiquantitative RT-PCR was used to study the effects on IAP mRNA expression. Transfections with a variety of IAP-luciferase...

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Identifiers

PMID: 15774940
DOI: 10.1152/ajpgi.00037.2005

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