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Article

Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation.

15 Apr 1996

Abstract excerpt

The expression of the constituent alpha 1 chain of laminin-1, a major component of basement membranes, is markedly regulated during development and differentiation. We have designed an antisense RNA strategy to analyze the direct involvement of the alpha 1 chain in laminin assembly, basement membrane formation, and cell differentiation. We report that the absence of alpha 1-chain expression, resulting from the...

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PMID: 8609173
DOI: 10.1083/jcb.133.2.417

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