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Article

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Cancer letters - 1 Feb 2017

Platet Nadine, Hinkel Isabelle, Richert Ludovic, Murdamoothoo Devadarssen, Moufok-Sadoun Ahlam, Vanier Marie, Lavalle Philippe, Gaiddon Christian, Vautier Dominique, Freund Jean-Noel, Gross Isabelle

Abstract excerpt

The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription factor essential for gut development, acts as a colon-specific tumor suppressor and opposes...

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Identifiers

PMID: 27816490
DOI: 10.1016/j.canlet.2016.10.040

Genes

CDX2
RHO
AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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