Differential regulation of pituitary-specific gene expression by insulin-like growth factor 1 in rat pituitary GH4C1 and GH3 cells.

doi:10.1210/endo.138.12.5585

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Article

Differential regulation of pituitary-specific gene expression by insulin-like growth factor 1 in rat pituitary GH4C1 and GH3 cells.

Endocrinology - 1 Dec 1997

Castillo A I, Aranda A

Abstract excerpt

We have compared the influence of insulin-like growth factor 1 (IGF-1) on pituitary gene expression in the rat cell lines GH4C1 and GH3. Incubation with IGF-1 increased PRL messenger RNA (mRNA) levels in GH4C1 cells by 4- to 5-fold but decreased the levels of PRL transcripts in GH3 cells. In addi...

Topics

Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Line
DNA-Binding Proteins
Gene Expression Regulation
Genes, ras
Growth Hormone
Half-Life
Insulin-Like Growth Factor I
Mutation
Pituitary Gland
Prolactin
Promoter Regions, Genetic
RNA, Messenger
Rats
Transcription Factor Pit-1
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9389530
DOI: 10.1210/endo.138.12.5585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9389530-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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