Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter.

doi:10.1093/nar/18.17.5235

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Article

Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter.

Nucleic acids research - 11 Sept 1990

Schaufele F, West B L, Reudelhuber T

Abstract excerpt

Nuclear extracts prepared from growth hormone-secreting (GC) and prolactin-secreting (235-1) rat anterior pituitary cell lines were compared for their ability to bind to the DNA sequences conferring tissue-specificity to the expression of the rat growth hormone (rGH) gene promoter. Cell-specific differences in the interaction of Pit-1, a tissue-specific member of the POU-domain transcription factor family, with...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
DNA-Binding Proteins
Deoxyribonuclease I
Gene Expression Regulation
Genes, Homeobox
Growth Hormone
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Organ Specificity

Prolactin

Promoter Regions, Genetic

Rats

Transcription Factor Pit-1

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 1976240
DOI: 10.1093/nar/18.17.5235
PMCID: PMC332147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1976240-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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