Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

doi:10.1210/endo.131.5.1425415

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Article

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

Endocrinology - 1 Nov 1992

Weber M M, Melmed S, Rosenbloom J, Yamasaki H, Prager D

Abstract excerpt

The anterior pituitary contains insulin-like growth factor-II (IGF-II) and expresses abundant IGF-II-binding sites, but the IGF-II signaling pathway in the pituitary has not been defined. We, therefore, tested the effects of recombinant human IGF-II on pituitary function by assessing the GH respo...

Topics

Animals
Cells, Cultured
DNA
Dose-Response Relationship, Drug
Growth Hormone
Insulin-Like Growth Factor II
Iodine Radioisotopes
Ligands
Male
Mutation
Pituitary Gland, Anterior
Radioimmunoassay
Rats
Receptor, IGF Type 1
Signal Transduction
Transfection
Triiodothyronine

Source

Open in PubMed

Identifiers

PMID: 1425415
DOI: 10.1210/endo.131.5.1425415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1425415-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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