Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

Endocrinology - 1 Nov 1992

Weber M M, Melmed S, Rosenbloom J, Yamasaki H, Prager D

Abstract excerpt

The anterior pituitary contains insulin-like growth factor-II (IGF-II) and expresses abundant IGF-II-binding sites, but the IGF-II signaling pathway in the pituitary has not been defined. We, therefore, tested the effects of recombinant human IGF-II on pituitary function by assessing the GH responsiveness of the primary rat somatotroph to IGF-II. IGF-II (3.3 nM) suppressed GH secretion by 50%, similar to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to DNA
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ligands

Share to Mutation

Share to Signal Transduction

Share to Transfection

Source

Identifiers

PMID: 1425415
DOI: 10.1210/endo.131.5.1425415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.PMID 1425415Read ↗

IGF-I receptor signalling: lessons from the somatotroph.Semantic proximity Read ↗

Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant.Semantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

Insulin-like growth factor -I deficiency.Semantic proximity Read ↗

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthSemantic proximity Read ↗

Comparative endocrinology of the insulin-like growth factor-binding proteinSemantic proximity Read ↗

The decline and fall of the IGF‐I receptorSemantic proximity Read ↗

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.Semantic proximity Read ↗

Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor.Semantic proximity Read ↗

The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of GrowthSemantic proximity Read ↗

Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b.Semantic proximity Read ↗

Targeting the IGF-1R: The Tale of the Tortoise and the HareSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.