Article

Kill two birds with one stone: making multi-transgenic pre-diabetes mouse models through insulin resistance and pancreatic apoptosis pathogenesis

2017-11-28

Abstract excerpt

<h4>Background: </h4> Type 2 diabetes, a chronic disease to which susceptibility is hereditary, is characterized by insulin resistance accompanied by defective insulin secretion. Mouse models, especially transgenic mice, play an important role in medical research. However, the transgenic mouse models that have been used in diabetes research are involved with single transgenes, focusing on the insulin gene or its m...

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Literature Corpus work: 704adb2f-f53e-593c-b6e4-9747f8443b71
DOI: 10.7287/peerj.preprints.3437v1

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