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Article

Multistep control of pituitary organogenesis.

Science (New York, N.Y.) - 5 Dec 1997

Sheng H Z, Moriyama K, Yamashita T, Li H, Potter S S, Mahon K A, Westphal H

Abstract excerpt

Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and...

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Source

Identifiers

PMID: 9388186
DOI: 10.1126/science.278.5344.1809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Multistep control of pituitary organogenesis.PMID 9388186Read ↗

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.Semantic proximity Read ↗

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Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.Semantic proximity Read ↗

Pitx2is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specificationSemantic proximity Read ↗

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.Semantic proximity Read ↗

Genetic Regulation of Pituitary Gland Development in Human and MouseSemantic proximity Read ↗

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.Semantic proximity Read ↗

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Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.Semantic proximity Read ↗

pitx3 defines an equivalence domain for lens and anterior pituitary placode.Semantic proximity Read ↗

LHX3 and LHX4 transcription factors in pituitary development and disease.Semantic proximity Read ↗

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