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Article

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

Molecular and cellular endocrinology - 1 Feb 2007

Mullen Rachel D, Colvin Stephanie C, Hunter Chad S, Savage Jesse J, Walvoord Emily C, Bhangoo Amrit P S, Ten Svetlana, Weigel Johannes, Pfäffle Roland W, Rhodes Simon J

Abstract excerpt

The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features...

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Source

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Identifiers

PMID: 17210222
DOI: 10.1016/j.mce.2006.12.019
PMCID: PMC1853274

Genes

LHX3
LHX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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