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Article

LHX3 and LHX4 transcription factors in pituitary development and disease.

Pediatric endocrinology reviews : PER - 1 Jan 2009

Colvin Stephanie C, Mullen Rachel D, Pfaeffle Roland W, Rhodes Simon J

Abstract excerpt

The LHX3 and LHX4 LIM-homeodomain proteins are regulatory transcription factors that play overlapping but distinct functions during the establishment of the specialized cells of the mammalian pituitary gland and the nervous system. Recent studies have identified a variety of mutations in the LHX3 and LHX4 genes in patients with combined pituitary hormone deficiency diseases. These patients have complex and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19337183

Genes

LHX3
LHX4
GLI2
HESX1
PROP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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