Article
Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.
Science (New York, N.Y.) - 17 May 1996
Sheng H Z, Zhadanov A B, Mosinger B, Fujii T, Bertuzzi S, Grinberg A, Lee E J, Huang S P, Mahon K A, Westphal H
Abstract excerpt
During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Targeted gene disruption in mice showed that Lhx3, a LIM homeobox gene expressed in the pituitary throughout development, is essential for differentiation and proliferation of pituitary cell lineages. In mice...
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