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Article

Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development.

Mechanisms of development - 1 Aug 2006

Zhao Yangu, Morales Donna Chelle, Hermesz Edit, Lee Woon-Kyu, Pfaff Samuel L, Westphal Heiner

Abstract excerpt

The formation of the anterior and intermediate lobes of the pituitary gland is a multi-step process regulated by cell-cell interactions involving a number of signaling pathways and by cascades of cell-intrinsic transcription factors. The LIM-homeodoamin protein Lhx3 has previously been shown to play an essential role in the growth of Rathke's pouch, a primordium of the anterior and intermediate lobes of the...

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Identifiers

PMID: 16859901
DOI: 10.1016/j.mod.2006.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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