Article
Molecular genetic analysis of TGF-beta1 in ovarian neoplasia.
Journal of experimental & clinical cancer research : CR - 1 Mar 1997
Cardillo M R, Yap E, Castagna G
Abstract excerpt
Malignant ovarian tumours have been associated with a loss of autocrine growth inhibition by transforming growth factor-beta. This study aimed to detect abnormalities in the gene structure, expression and localization of TGF-beta1, in paraffin-embedded samples from 31 ovarian neoplasias (21 malignant, 5 borderline and 5 benign). Gene mutations in the region coding for the active protein were detected by PCR-SSCP...
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