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Article

IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer

19 Nov 2004

Abstract excerpt

Recent investigations support an important role for TGF-beta in the development of colorectal cancer. However, the molecular consequences of TGF-beta signaling in the colon remains incompletely understood. In a recent study in Immunity, we analyzed the role of TGF-beta in a murine model of colon cancer. Using transgenic mice overexpressing TGF-beta or a dominant negative TGF-beta receptor II under control of the...

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PMID: 15655344
DOI: 10.4161/cc.4.2.1413

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