Article
Genome scanning for segments shared identical by descent among distant relatives in isolated populations.
American journal of human genetics - 1 Oct 1997
Durham L K, Feingold E
Abstract excerpt
In this paper, we address some of the statistical issues concerning false-positive rates that arise when the whole genome, or a portion thereof, is scanned in distantly related individuals, to search for a disease locus. We derive a method for correcting false-positive probabilities for the large number of comparisons that are performed when scanning a large portion of the genome. We consider both the idealized...
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