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Article

Relationship estimation from whole-genome sequence data.

PLoS genetics - 1 Jan 2014

Li Hong, Glusman Gustavo, Hu Hao, Shankaracharya, Caballero Juan, Hubley Robert, Witherspoon David, Guthery Stephen L, Mauldin Denise E, Jorde Lynn B, Hood Leroy, Roach Jared C, Huff Chad D

Abstract excerpt

The determination of the relationship between a pair of individuals is a fundamental application of genetics. Previously, we and others have demonstrated that identity-by-descent (IBD) information generated from high-density single-nucleotide polymorphism (SNP) data can greatly improve the power and accuracy of genetic relationship detection. Whole-genome sequencing (WGS) marks the final step in increasing...

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PMID: 24497848
DOI: 10.1371/journal.pgen.1004144
PMCID: PMC3907355

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