Article
Atlas of Cryptic Genetic Relatedness Among 1000 Human Genomes.
Genome biology and evolution - 23 Feb 2016
Fedorova Larisa, Qiu Shuhao, Dutta Rajib, Fedorov Alexei
Abstract excerpt
A novel computational method for detecting identical-by-descent (IBD) chromosomal segments between sequenced genomes is presented. It utilizes the distribution patterns of very rare genetic variants (vrGVs), which have minor allele frequencies <0.2%. Contrary to the existing probabilistic approaches our method is rather deterministic, because it considers a group of very rare events which cannot happen together...
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