Article
Inference of identity by descent in population isolates and optimal sequencing studies.
European journal of human genetics : EJHG - 1 Oct 2013
Glodzik Dominik, Navarro Pau, Vitart Veronique, Hayward Caroline, McQuillan Ruth, Wild Sarah H, Dunlop Malcolm G, Rudan Igor, Campbell Harry, Haley Chris, Wright Alan F, Wilson James F, McKeigue Paul
Abstract excerpt
In an isolated population, individuals are likely to share large genetic regions inherited from common ancestors. Identity by descent (IBD) can be inferred from SNP genotypes, which is useful in a number of applications, including identifying genetic variants influencing complex disease risk, and planning efficient cohort-sequencing strategies. We present ANCHAP--a method for detecting IBD in isolated...
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