Article
MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte.
The American journal of physiology - 1 Jun 1999
Ortiz D F, Li S, Iyer R, Zhang X, Novikoff P, Arias I M
Abstract excerpt
Bile secretion in liver is driven in large part by ATP-binding cassette (ABC)-type proteins that reside in the canalicular membrane and effect ATP-dependent transport of bile acids, phospholipids, and non-bile acid organic anions. Canalicular ABC-type proteins can be classified into two subfamilies based on membrane topology and sequence identity: MDR1, MDR3, and SPGP resemble the multidrug resistance (MDR)...
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