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Article

Homogeneous genotyping assays for single nucleotide polymorphisms with fluorescence resonance energy transfer detection.

Genetic analysis : biomolecular engineering - 1 Feb 1999

Chen X, Kwok P Y

Abstract excerpt

A homogeneous detection mechanism based on fluorescence resonance energy transfer (FRET) has been developed for two DNA diagnostic tests. In the template-directed dye-terminator incorporation (TDI) assay, a donor dye-labeled primer is extended by DNA polymerase using allele-specific, acceptor dye-labeled ddNTPs. In the dye-labeled oligonucleotide ligation (DOL) assay, a donor dye-labeled common probe is joined to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 10084108
DOI: 10.1016/s1050-3862(98)00016-3

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