Article
Association of a polymorphism in the dopamine-transporter gene with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Sept 1997
Le Couteur D G, Leighton P W, McCann S J, Pond S m
Abstract excerpt
The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins. Therefore, we investigated whether a polymorphic region in the 3'-untranslated region of the dopamine-transporter gene is...
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