Article
Association of tau gene polymorphism with Parkinson's disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Oct 2003
Zappia M, Annesi G, Nicoletti G, Serra P, Arabia G, Pugliese P, Messina D, Caracciolo M, Romeo N, Annesi F, Pasqua A A, Spadafora P, Civitelli D, Romeo N, Epifanio A, Morgante L, Quattrone A
Abstract excerpt
We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95%...
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