Article
Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population.
Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2009
Shahabi H Niazi, Westberg L, Melke J, Håkansson A, Belin A Carmine, Sydow O, Olson L, Holmberg B, Nissbrandt H
Abstract excerpt
Cytochrome P450 2E1 (CYP2E1), which inter alia is located in dopamine containing neurons in the substantia nigra, has been hypothesized to be of importance for the pathophysiology of Parkinson's disease (PD), either by its production of reactive oxygen species (ROS) or by its capability to detoxify putative neurotoxins. Numerous polymorphisms in the coding and non-coding regions of the gene for this enzyme have...
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