Article
The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.
Movement disorders : official journal of the Movement Disorder Society - 1 Sept 1997
Kösel S, Egensperger R, Schnopp N M, Graeber M B
Abstract excerpt
Previous studies have estimated levels of mitochondrial DNA (mtDNA) carrying the 4,977-base-pair 'common deletion' in tissues from patients with Parkinson's disease (PD) by using semiquantitative techniques. The role of this deleted mtDNA species in the pathogenesis of PD has remained controversial. We have applied competitive polymerase chain reaction to achieve exact quantitation of deleted mtDNA in the...
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