Article
Quantitation of a mitochondrial DNA deletion in Parkinson's disease.
FEBS letters - 16 Mar 1992
Mann V M, Cooper J M, Schapira A H
Abstract excerpt
A 5 kilobase deletion in mitochondrial DNA (mtDNA) has been reported to be responsible for the specific complex I deficiency in the substantia nigra (SN) of the Parkinson's disease (PD) brain. We have studied mitochondrial respiratory chain function in the SN from control and PD subjects, and analysed mtDNA, extracted from the same tissues, by Southern blot and the polymerase chain reaction (PCR). Quantitation of...
Topics
- Blotting, Southern
- DNA, Mitochondrial
- Humans
- Mutation
- Parkinson Disease
- Polymerase Chain Reaction
- Substantia Nigra