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Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson’s disease? A critical reappraisal

19 Mar 2021

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disease manifesting both motor and non-motor symptoms. The motor features are generally ascribed to the selective loss of dopamine neurons within the substantia nigra pars compacta. While the precise etiology of PD remains elusive, multiple genetic and environmental elements have emerged as contributing factors. The discovery of MPTP-induced parkinsonism...

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PMID: 33745923
DOI: 10.1016/j.brainres.2021.147434

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