Article
The absence of myelin P0 protein produces a novel molecular phenotype in Schwann cells.
Annals of the New York Academy of Sciences - 14 Sept 1999
Menichella D M, Xu W, Jiang H, Sohi J, Vallat J M, Baron P, Kamholz J, Shy M
Abstract excerpt
In order to better understand the pathogenesis of demyelination in P0 knockout (P0-/-) mice, we analyzed the myelin gene expression and the localization of myelin proteins in P0 null mouse sciatic nerve. We have demonstrated that the severe demyelinating neuropathy of P0-knockout mouse is associated with changes in the program of myelin gene expression. Some changes in myelin gene expression occur early, others...
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