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Article

Beta-catenin mutations in cell lines established from human colorectal cancers.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997

Ilyas M, Tomlinson I P, Rowan A, Pignatelli M, Bodmer W F

Abstract excerpt

beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT-PCR) and direct sequencing of 23 human colorectal cancer cell lines from 21 patients. In two cell lines, there was...

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Identifiers

PMID: 9294210
DOI: 10.1073/pnas.94.19.10330
PMCID: PMC23362

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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