Article
Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines.
Melanoma research - 1 Apr 2002
Pollock P M, Hayward N
Abstract excerpt
Mutations in exon 3 of the CTNNB1 gene encoding beta-catenin have been reported in colorectal cancer cell lines and tumours. Although one study reported mutations or deletions affecting beta-catenin in 20% of melanoma cell lines, subsequent reports detected a much lower frequency of aberrations in uncultured melanomas. To determine whether this difference in mutation frequency reflected an in vitro culturing...
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