Article
Transduction of Apaf-1 or caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediated apoptosis.
Biochemical and biophysical research communications - 16 Jun 2000
Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H
Abstract excerpt
p53 replacement gene therapy has been carried out clinically for cancers with p53 mutations; however, some cancers are resistant to p53 gene therapy. In this study, we transduced A-172 and U251 cells harboring p53 mutations with wild-type p53 using adenovirus vectors to induce wild-type p53 protein at similar expression levels. A-172 cells did not undergo apoptosis after p53 transduction, whereas U251 cells were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.