Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.

The Journal of biological chemistry - 5 Jan 2007

Patel Jagruti H, McMahon Steven B

Abstract excerpt

The c-MYC oncoprotein is among the most potent transforming agents in human cells. Ironically, c-MYC is also capable of inducing massive apoptosis under certain conditions. A clear understanding of the distinct pathways activated by c-MYC during apoptosis induction and transformation is crucial to the design of therapeutic strategies aimed at selectively reactivating the apoptotic potential of c-MYC in cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Electroporation
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Plasmids

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Transcriptional Activation

Source

Identifiers

PMID: 17082179
DOI: 10.1074/jbc.M609138200

Genes

MYC
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.PMID 17082179Read ↗

Targeting of Miz-1 is essential for Myc-mediated apoptosis.Semantic proximity Read ↗

Attacking cancer's Achilles heel: antagonism of anti‐apoptotic <scp>BCL</scp>‐2 family membersSemantic proximity Read ↗

Toward Targeting Antiapoptotic MCL-1 for Cancer TherapySemantic proximity Read ↗

Mcl‐1 targeting could be an intriguing perspective to cure cancerSemantic proximity Read ↗

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.Semantic proximity Read ↗

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.Semantic proximity Read ↗

Role of Three Cancer ≪Master Genes≫ P53, Bcl2 and C-Myc on the Apoptotic ProcessSemantic proximity Read ↗

The role of the Bcl-2 protein family in cancer.Semantic proximity Read ↗

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.Semantic proximity Read ↗

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapySemantic proximity Read ↗

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.Semantic proximity Read ↗

Induction of apoptosis by the c-Myc helix-loop-helix/leucine zipper domain in mouse 3T3-L1 fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.