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Article

Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.

Oncogene - 27 Oct 2005

Schwerk Christian, Schulze-Osthoff Klaus

Abstract excerpt

We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types. The phenotypical outcome and form of cell death was strikingly dependent on the AdOx...

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Identifiers

PMID: 16007140
DOI: 10.1038/sj.onc.1208855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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