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Article

Loss of mitochondrial DNA enhances angiogenic and invasive potential of hepatoma cells.

Oncology reports - 1 Mar 2010

Cheon Hwanju, Moon Hyo-Eun, Lee Myung-Shik, Kim Soung Soo

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are frequently found in a variety of tumors. However, the role of mtDNA mutations in tumor behavior is poorly understood. We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells. Expression of hypoxia inducible factor (HIF)-2alpha mRNA was markedly increased in rho0 cells compared to control cells. Protein level of...

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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Liver Neoplasms

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Share to Vascular Endothelial Growth Factor A

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Identifiers

PMID: 20127020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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