Article

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8 <sup>+</sup> T Cells

2023-02-03

Abstract excerpt

The accepted paradigm for both cellular and antitumor immunity relies upon tumor cell kill by CD8 + T cells recognizing cognate antigens presented in the context of target cell major histocompatibility complex class I (MHC I) molecules. Likewise, a classically described mechanism of tumor immune escape is tumor MHC-I downregulation. Here, we report that CD8 + T cells maintain the capacity to kill tumor cells tha...

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Literature Corpus work: 5ac1f69d-8143-5c03-a958-f3f206eb260d
DOI: 10.1101/2023.02.02.526713

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