Article
Recognition of neuroectodermal tumors by melanoma-specific cytotoxic T lymphocytes: evidence for antigen sharing by tumors derived from the neural crest.
Cancer immunology, immunotherapy : CII - 1 Aug 1994
Shamamian P, Mancini M, Kawakami Y, Restifo N P, Rosenberg S A, Topalian S L
Abstract excerpt
Melanomas from different patients have been shown to express shared tumor antigens, which can be recognized in the context of the appropriate MHC class I molecules by cytolytic T cells. To determine if T-cell-defined melanoma antigens are expressed on other tumors of neuroectodermal origin, four melanoma-specific cytotoxic T lymphocyte (CTL) cultures derived from tumor-infiltrating lymphocytes (TIL) were tested...
Topics
- Animals
- Antibodies, Neoplasm
- Antigens, Neoplasm
- Cytotoxicity, Immunologic
- Epitopes
- Female
- HLA-A2 Antigen
- Histocompatibility Antigens Class I
- Humans
- Interferon-gamma