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Article

The domain order of mammalian capping enzyme can be inverted and baculovirus phosphatase can function in cap formation in vivo.

Virology - 20 Dec 2002

Martins Alexandra, Shuman Stewart

Abstract excerpt

The bifunctional mammalian mRNA capping enzyme (Mce1) consists of an N-terminal triphosphatase domain Mce1(1-210) fused to a C-terminal guanylyltransferase domain Mce1(211-597). The physical domain order H(2)N-triphosphatase-guanylyltransferase-COOH mimics the temporal order of the capping reactions. To determine if the physical domain order is functionally important in vivo, we engineered an "inverted" mammalian...

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PMID: 12504559
DOI: 10.1006/viro.2002.1606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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