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Article

A yeast-based genetic system for functional analysis of viral mRNA capping enzymes.

Journal of virology - 1 Jun 2000

Ho C K, Martins A, Shuman S

Abstract excerpt

Virus-encoded mRNA capping enzymes are attractive targets for antiviral therapy, but functional studies have been limited by the lack of genetically tractable in vivo systems that focus exclusively on the RNA-processing activities of the viral proteins. Here we have developed such a system by engineering a viral capping enzyme-vaccinia virus D1(1-545)p, an RNA triphosphatase and RNA guanylyltransferase-to...

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Identifiers

PMID: 10823853
DOI: 10.1128/jvi.74.12.5486-5494.2000
PMCID: PMC112033

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A yeast-based genetic system for functional analysis of viral mRNA capping enzymes.PMID 10823853Read ↗

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