Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2).

Molecular and cellular biology - 1 May 2007

Fullerton Morgan D, Hakimuddin Fatima, Bakovic Marica

Abstract excerpt

The CDP-ethanolamine pathway is responsible for the de novo biosynthesis of ethanolamine phospholipids, where CDP-ethanolamine is coupled with diacylglycerols to form phosphatidylethanolamine. We have disrupted the mouse gene encoding CTP:phosphoethanolamine cytidylyltransferase, Pcyt2, the main regulatory enzyme in this pathway. Intercrossings of Pcyt2(+/-) animals resulted in small litter sizes and unexpected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Fatty Acids
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Mitochondria

Share to Phospholipids

Share to RNA Nucleotidyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 17325045
DOI: 10.1128/MCB.01527-06
PMCID: PMC1899976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2).PMID 17325045Read ↗

Complementation of the metabolic defect in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)-deficient primary hepatocytes.Semantic proximity Read ↗

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase.Semantic proximity Read ↗

Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegiaSemantic proximity Read ↗

Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.Semantic proximity Read ↗

Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation.Semantic proximity Read ↗

Pcyt2 Deficiency Causes Age-Dependant Development of Non-Alcoholic Steatohepatitis and Insulin Resistance that Could be Attenuated with Phospho-EthanolamineSemantic proximity Read ↗

Critical role of PCYT2 in muscle health and agingSemantic proximity Read ↗

Phosphoethanolamine reverses aberrant DNA methylation in non-alcoholic steatohepatitis caused by Pcyt2 deficiencySemantic proximity Read ↗

The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity.Semantic proximity Read ↗

Insights into the requirement of phosphatidylcholine synthesis for liver function in mice.Semantic proximity Read ↗

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.Semantic proximity Read ↗

Cloning and Expression of Mouse Liver Phosphatidylserine Synthase-1 cDNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.