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Mechanisms regulating resistance to inhibitors of topoisomerase II

1 Jan 2013

Abstract excerpt

Inhibitors of topoisomerase II (topo II) are clinically effective in the management of hematological malignancies and solid tumors. The efficacy of anti-tumor drugs targeting topo II is often limited by resistance and studies with in vitro cell culture models have provided several insights on potential mechanisms. Multidrug transporters that are involved in the efflux and consequently reduced cytotoxicity of...

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PMID: 23914174
DOI: 10.3389/fphar.2013.00089

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