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DNA topoisomerase II mutations and resistance to anti-tumor drugs.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Sept 1995

Vassetzky Y S, Alghisi G C, Gasser S M

Abstract excerpt

Mutations in DNA topoisomerase II are often correlated with drug-resistance in tumor cell lines. Studies of topoisomerase II-mediated drug-resistance in various model systems, as well as the sequencing of such mutations from drug-resistant tumors, have shed light on the functional domains of topo...

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PMID: 8763829
DOI: 10.1002/bies.950170906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8763829-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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