Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.

doi:10.1016/s0167-4781(98)00140-7

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Article

Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.

Biochimica et biophysica acta - 1 Oct 1998

Larsen A K, Skladanowski A

Abstract excerpt

DNA topoisomerase inhibitors are important antineoplastic agents used in the treatment of both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical usefulness is limited by both natural and acquired tumor cell resistance, which almost always is multifactorial in natu...

Topics

Antineoplastic Agents
Cell Cycle
Cell Death
Cell Division
DNA Repair
DNA Topoisomerases, Type I
Drug Resistance
Enzyme Inhibitors
Humans
Mutation
Neoplasms
Recombination, Genetic
Topoisomerase I Inhibitors

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