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Article

Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death.

Biochimica et biophysica acta - 1 Oct 1998

Larsen A K, Skladanowski A

Abstract excerpt

DNA topoisomerase inhibitors are important antineoplastic agents used in the treatment of both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical usefulness is limited by both natural and acquired tumor cell resistance, which almost always is multifactorial in nature. The resistance can be due to pretarget events, such as drug accumulation, metabolism and intracellular drug...

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Identifiers

PMID: 9748618
DOI: 10.1016/s0167-4781(98)00140-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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