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Article

Mechanisms of camptothecin resistance by human topoisomerase I mutations.

Journal of molecular biology - 11 Jun 2004

Chrencik Jill E, Staker Bart L, Burgin Alex B, Pourquier Philippe, Pommier Yves, Stewart Lance, Redinbo Matthew R

Abstract excerpt

Human topoisomerase I relaxes superhelical tension associated with DNA replication, transcription and recombination by reversibly nicking one strand of duplex DNA and forming a covalent 3'-phosphotyrosine linkage. This enzyme is the sole target of the camptothecin family of anticancer compounds, which acts by stabilizing the covalent protein-DNA complex and enhancing apoptosis through blocking the advancement of...

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Identifiers

PMID: 15165849
DOI: 10.1016/j.jmb.2004.03.077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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