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Article

Targeting topoisomerase I: molecular mechanisms and cellular determinants of response to topoisomerase I inhibitors

9 Sept 2008

Abstract excerpt

BACKGROUND: Topoisomerase I is required for DNA relaxation during critical cellular functions. The identification of camptothecins as specific enzyme inhibitors and their clinical efficacy have stimulated extensive efforts to exploit topoisomerase I as a tumor target and explain the putative mechanisms of antitumor-specific action. OBJECTIVE: This review provides an overview of the recent achievements in the...

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PMID: 18781823
DOI: 10.1517/14728222.12.10.1243

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