Article
Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.
Antimicrobial agents and chemotherapy - 1 Nov 1997
Douglas C M, D'Ippolito J A, Shei G J, Meinz M, Onishi J, Marrinan J A, Li W, Abruzzo G K, Flattery A, Bartizal K, Mitchell A, Kurtz M B
Abstract excerpt
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a gene from the diploid organism Candida albicans that encodes a target of these inhibitors. A 2.1-kb p...
Topics
- Amino Acid Sequence
- Animals
- Antifungal Agents
- Base Sequence
- Candida albicans
- Drug Resistance, Microbial
- Echinocandins
- Enzyme Inhibitors
- Fungal Proteins
- Genotype
- Glucosyltransferases
- Membrane Proteins
- Mice
- Molecular Sequence Data