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Article

Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin.

Medical mycology - 1 May 2005

Gardiner R E, Souteropoulos P, Park S, Perlin D S

Abstract excerpt

Caspofungin acetate (CAS) is a member of a new class of clinically-approved echinocandin drugs to treat invasive aspergillosis. CAS inhibits the activity of beta-1,3-D-glucan synthase (GS), thus damaging the fungal cell wall. Although no clinical resistance of Aspergillus to CAS has been reported as yet, the development of in vitro reduced susceptibility is presumed to be inevitable. By contrast, echinocandin...

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Identifiers

PMID: 16110824
DOI: 10.1080/13693780400029023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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