Article
Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.
Antimicrobial agents and chemotherapy - 1 Feb 2000
Onishi J, Meinz M, Thompson J, Curotto J, Dreikorn S, Rosenbach M, Douglas C, Abruzzo G, Flattery A, Kong L, Cabello A, Vicente F, Pelaez F, Diez M T, Martin I, Bills G, Giacobbe R, Dombrowski A, Schwartz R, Morris S, Harris G, Tsipouras A, Wilson K, Kurtz M B
Abstract excerpt
The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised patients. Natural-product inhibitors of cell wall (1,3)-beta-D-glucan synthase such as lipopeptide pneumocandins and echinocandins as well as the glycolipid papulacandins have been evaluated as potential therapeutics for...
Topics
- Antifungal Agents
- Candida albicans
- Echinocandins
- Enzyme Inhibitors
- Fungal Proteins
- Glucans
- Glucosyltransferases
- Membrane Proteins
- Mutation
- Saccharomyces