Article
Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.
Infection and immunity - 1 Aug 1996
Kurtz M B, Abruzzo G, Flattery A, Bartizal K, Marrinan J A, Li W, Milligan J, Nollstadt K, Douglas C M
Abstract excerpt
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic class for treating serious fungal infections is the potential for drug resistance development. In...
Topics
- Animals
- Anti-Bacterial Agents
- Antifungal Agents
- Candida albicans
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Echinocandins
- Female
- Fungal Proteins
- Genes, Dominant
- Glucosyltransferases
- Lethal Dose 50
- Mice
- Mice, Inbred DBA
- Microbial Sensitivity Tests