Article
Molecular genetic analysis of giant cell glioblastomas.
The American journal of pathology - 1 Sept 1997
Meyer-Puttlitz B, Hayashi Y, Waha A, Rollbrocker B, Boström J, Wiestler O D, Louis D N, Reifenberger G, von Deimling A
Abstract excerpt
Glioblastomas (GBMs) are a heterogeneous group of tumors. Recently, distinct molecular genetic alterations have been linked to subgroups of patients with GBM. Giant cell (gc)GBMs are a rare variant of GBM characterized by a marked preponderance of multinucleated giant cells. Several reports have...
Topics
- Adult
- Aged
- Carrier Proteins
- Child
- Chromosome Aberrations
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- ErbB Receptors
- Female
- Gene Deletion
- Genes, p53
- Giant Cells
- Glioblastoma
- Humans
- Male
- Middle Aged
- Mutation